RecruitingNot Applicable

Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography

Hong Kong140 participantsStarted 2016-08-22

Plain-language summary

This study is to elucidate the morphologic evolution and remodeling of ICAD under stringent control of cardiovascular risk factors.

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Patient is 30 to 85 years of age, inclusive.
✓. Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism and a relevant intracranial atherosclerotic stenosis ≥60%.
✓. Patient who has no contra-indication for the proposed imaging tests.
✓. Patient understands the purpose and requirements of the study, and has provided an informed consent.

✕. Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease or primary angiitis of CNS.
✕. A tandem stenosis \>50% at extra-cranial internal carotid artery.
✕. Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \<100 x 109/L), coagulopathy (INR \>1.5).
✕. A medical condition that would not allow the patient to adhere to the protocol or complete the study.

Morphologic Evolution and Remodeling of Intracranial Atherosclerosis

Timeframe: Dec, 2019

NCT IDNCT03295773

SponsorChinese University of Hong Kong

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-28

Thomas Wai Hong LEUNG, FRCP