CompletedNot Applicable

Yoga for Symptoms of Nerve Damage Caused by Chemotherapy

United States51 participantsStarted 2017-09-18

Plain-language summary

Some types of chemotherapy used to treat breast cancer can cause damage to nerves with symptoms like tingling, numbness, muscle weakness, and pain in the hands and feet that can last and can affect functioning. The purpose of this study is to find out the effects of yoga on reducing symptoms caused by such nerve damage.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * English-speaking * Age \>/= 18 years old * Survivors with a primary diagnosis of stage I-III breast, ovarian uterine, or endometrial cancer * Moderate to severe chemotherapy induced peripheral neuropathy, defined by symptoms such as numbness, tingling, or pain ratings of 4 or greater on a 0-10 numeric rating scale * Have completed neurotoxic chemotherapy, i.e. taxanes (paclitaxel, docetaxel) and platinum (carboplatin) at least 3 months prior to enrollment * If taking anti-neuropathy medications, they are on a stable regiment (no change in 3 months) * ECOG performance status 0-2 Exclusion Criteria: * Participants with metastatic disease * Participants who are currently receiving physical therapy or practicing yoga for any reason Control Group - Inclusion/Exclusion Criteria Inclusion Criteria: * English speaking * Age \>/= 18 years old * Survivors with a primary diagnosis of Stage I-III breast, ovarian, uterine, or endometrial cancer * CIPN symptoms such as numbness, tingling, or pain ratings \< 2 on a 0-10 NRS scale * Have completed neurotoxic chemotherapy, i.e. taxanes (paclitaxel, docetaxel) and platinum (carboplatin) at least 3 months prior to enrollment * ECOG performance status 0-2 Exclusion Criteria: * Patients with metastatic disease * Patients taking anti-neuropathy medication * Patients who are currently receiving physical therapy or practicing yoga for any reason

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in treatment related peripheral neuropathy symptoms

Timeframe: 8 weeks of the participants' most bothersome peripheral neuropathy symptom

Trial details

NCT IDNCT03292328

SponsorMemorial Sloan Kettering Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-09-15

View on ClinicalTrials.gov More Breast Cancer trials