CompletedNot Applicable

Determining the Impact of Shunting and CerebroVascular Reactivity on 7T MRI (DISCoVeR 7T MRI)

United States27 participantsStarted 2017-10-26

Plain-language summary

The purpose of this study is to use transcanial doppler (TCD) ultrasound to look for possible risk factors for ischemic brain injury. We will perform contrast TCD with agitated saline contrast to identify and contrast right-to-left shunt (RLS) and breath holding to assess cerebrovascular reactivity (CVR) in the elderly.

Who can participate

Age range60 Years

SexALL

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Inclusion criteria

✓. Males and females ≥ 60 years of age.
✓. Fluent in English.
✓. Part of the NACC longitudinal cohort (Protocol #: 068200) of the PMC/ADCC with consensus conference designation of cognitively normal, Mild Cognitive Impairment, or probable/possible Alzheimer's disease.
✓. Has consented to participate in the ADCC high-resolution MRI sub-study.
✓. NACC longitudinal visit must be within 6 months of the TCD study and brain MRI study.
✓. Women: post-menopausal or surgically sterile.
✓. Willing and able to complete all required study procedures.
✓. Completed 6 grades of education.

Exclusion criteria

✕. Prior clinically symptomatic ischemic or hemorrhagic stroke.
✕. Inability to tolerate or contraindication to TCD study in the opinion of an investigator or treating physician.
✕. Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study.

What they're measuring

Presence of right-to-left shunt on TCD

Timeframe: Baseline

Presence of cerebrovascular reactivity on TCD

Timeframe: Baseline

Trial details

NCT IDNCT03291340

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-10-01

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