CompletedNot Applicable

Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level

France200 participantsStarted 2017-01

Plain-language summary

The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications. The investigators hypothesize that an increase of the preoperative stimulation of vasopressinergic system (in response to acute or chronic conditions) could lead to a microcirculatory dysfunction and favor the occurrence of vasodilatation during and after CPB and increase the symptoms of an inflammatory response after CPB. By defining a high risk population, a targeted strategy of monitoring and early or preventive treatment could improve postoperative prognosis.

Who can participate

Age range18 Years – 81 Years

SexALL

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Inclusion Criteria: * Elective surgery * Scheduled time of at least 24 hours * Cardiopulmonary bypass Exclusion Criteria: * Urgent surgery within 24 hours of hospital admission * Chronic renal failure with preoperative glomerular filtration rate below 45 ml/min * Ongoing sepsis (ie uncontrolled endocarditis) * Immunosuppressive therapy (solid organ transplant recipient) * Previously included in this study

What they're measuring

Preoperative copeptin level

Timeframe: Preoperative 24 hours

Trial details

NCT IDNCT03288610

SponsorUniversity Hospital, Montpellier

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2017-07

View on ClinicalTrials.gov More Systemic Inflammatory Response Syndrome (SIRS) trials