CompletedNot Applicable

Dysregulated CNS Inflammation After Acute Brain Injury

United States8 participantsStarted 2018-01-02

Plain-language summary

By doing this study, the investigator hopes to learn how the levels of important proteins involved in inflammation change over time in patients with acute brain injury. The total amount of time participants will be asked to volunteer for this study is approximately two hours over a five day period.

Who can participate

Age range18 Years – 101 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * severe, non-penetrating TBI or aSAH * must have a ventriculostomy (EVD) placed by the UK Neurosurgery service within 12 hours of primary traumatic episode Exclusion Criteria: * non-survivable brain injury or other organ system injury * life expectancy is five days or less * penetrating TBI * status epilepticus upon arrival to the hospital * severe ischemic heart disease or congestive heart failure, myocardial infarction, or spinal cord injury * Takotsubo cardiomyopathy secondary to the SAH * active cancer or have been treated for cancer within the previous 6 months

What they're measuring

Severe TBI - Measure of temporal profile of inflammatory proteins in CSF

Timeframe: For 24 months from start of the study

Trial details

NCT IDNCT03287557

SponsorUniversity of Kentucky

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-05-24

View on ClinicalTrials.gov More Traumatic Brain Injury trials