Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty- Multi-center Trial

Inclusion Criteria: * Patient is ≥ 18 years of age * Patient has no open wounds on operative leg * Patient is scheduled to undergo elective total knee arthroplasty for posttraumatic, osteoarthritis, avascular necrosis, and/or inflammatory arthritis * Patient does not have active infection on the operative leg, the operative joint * Patient is willing to cooperate and follow study protocol and visit schedule Exclusion Criteria: * Patient is ≤ 18 years of age * Patient is pregnant * Patient is unable to provide written consent * Patient has psychiatric disorder that precludes safe study participation or that necessitates confinement in a custodial environment at home or in a chronic care facility * Patient has traumatic injury that requires emergent or urgent total knee arthroplasty (e.g. fracture) * Patient has active infections in the operative leg/joint * Patient has severe dementia * Suspicion of illicit drug abuse by patient. Patients who use prescription cannabinoids are not excluded from enrollment. * ASA score of 5 \& 6 * No application of topical antibiotic powder such as vancomycin or antibiotic beads in surgical wound * Intra-operative re-dosing other than specified re-dosing intervals or without excessive blood loss (\<1500mL) * History of prior native septic knee arthritis