Beta Adrenergic Antagonist for the Healing of Chronic DFU

Inclusion Criteria: * Male or female subject of any race 18 years old or older * Lower extremity ulcer located anywhere on the foot (as defined as beginning below the malleoli of the ankle): * Of more than 30 days duration and less than 2 years duration * Surface area between 0.5cm2 and 20cm2 (as measured with the Silhouette imaging system at randomization). The ulcer with largest surface area meeting inclusion criteria will be selected as index ulcer * If two ulcers present with the same surface area, the ulcer of the longest duration will be selected as index ulcer * Documented Ankle Brachial Index (ABI) between 0.8 and 1.2 on the study limb or toe pressure over 65mmHg within 3 months of screening phase * Documented biopsy report to rule out malignancy of ulcer of \> 6 months duration * Subject or legally authorized representative understands and is willing to give written informed consent * Subject or legally authorized representative is willing and able to comply with a trial (13 to 17 days) of protocol-specified standard care prior to randomization and to comply with all study requirements Exclusion Criteria: * Ulcer of non-diabetic etiology, such as venous, arterial and burn wounds * Index ulcer is less than 3 cm in distance from any other ulcer on the same extremity * There are greater than 3 ulcers on the study foot * Index ulcer presents with any of the following: cellulitis, osteomyelitis, exposed bone, tendon or fascia, capsule , purulent exudate or gangr…