UnknownNot Applicable

Effect of Orthoses and Underfoot Vibration on Balance in Neuropathy

United Kingdom15 participantsStarted 2017-10-20

Plain-language summary

A cross-sectional study which will look at the effects of AFO's and vibrating insoles on balance performance in people with CMT disease.

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Clinical or genetically confirmed diagnosis of CMT or related peripheral neuropathy
✓. Mixed sensory and motor presentation
✓. Over 18 years
✓. Able to stand unsupported for five minutes
✓. Able to walk for 50m with or without a walking stick or orthotic devices

✕. Presence of other significant neurological disorders (such as multiple sclerosis, cerebrovascular diseases, epilepsy, movement disorders), or major comorbidities (e.g. vestibular dysfunction, use of medication which may affect balance, cognitive impairment, presence of medical conditions in which exercise training may be detrimental).
✕. Presence of peripheral neuropathy caused by a condition other than CMT.
✕. Limb surgery during the six months prior to screening (or planned before final assessment).
✕. Women of child-bearing age if they are pregnant, planning a pregnancy during their time in the study or in the 12 weeks following giving birth. This is due to the effects of pregnancy on balance.

Posturography

Timeframe: 30 second caputer in a variety of conditions

force measures

Timeframe: 30 second caputer in a variety of conditions

NCT IDNCT03278093

SponsorSt George's, University of London

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-02-20

Magdalena Dudziec