A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment

Inclusion Criteria: * Adult patients meeting International Classification of Headache Disorders 3rd Edition (ICHD-3) criteria for a diagnosis of SIH (Table 1) who have had a contrast-enhanced brain MRI and a myelogram confirming the presence of a CSF leak will be recruited from the Duke Radiology spine intervention clinic \[25\] Exclusion Criteria: * recent (i.e., \< 2 weeks) blood patch * contraindication or inability to undergo the procedure * inability to provide informed consent * expected inability to complete follow-up assessment * a contraindication to receiving contrast material (precluding an epidurogram) * contraindication to receiving fibrin glue (i.e., allergy).