Short Term Effect of Glucocorticoids on Brown Adipose Tissue Thermogenesis in Humans

Inclusion Criteria: * Healthy male volunteers * BMI between 19-27 kg/m2 Exclusion Criteria: * Cold induced thermogenesis of less than 5% basal metabolic rate (determined during screening visit) * Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to class of drugs or the investigational product, * History of depressive disorder, anxiety disorder * History of tuberculosis or latent infection * Increased intraocular pressure * History of peptic / gastrointestinal ulcer disease * Concomitant medication: Non-steroidal anti-inflammatory drugs (NSAID), other glucocorticoids, diuretics, antihypertensives, fibrates or statins, metformin * Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus), * Hypersensitivity to cold (e.g. Raynaud Syndrome) * Allergy to local anesthetic * Known or suspected non-compliance, drug or alcohol abuse, * Inability to follow the procedures of the study * Participation in another study with investigational drug within the 30 days preceding and during the present study, * Previous enrolment into the current study, * Enrolment of the investigator, his/her family members, employees and other dependent persons, * Hypothyroidism without sufficient substitution * Claustrophobia * MRI incompatible implants * Enrolment into another study using ionizing radiation within the previous 12 months.