CompletedNot Applicable

Use of Topical Phenytoin in Bisphosphonate-related Osteonecrosis of the Mandible

20 participantsStarted 2012-09-01

Plain-language summary

Patients who had bisphosphonate-related osteonecrosis of the jaw in stage II were allocated in two groups randomly : In group1, 10 patients underwent debridement and primary closer of the area,in group 2 , patients received Phenytoin + tetracycline topically in the debridement area.Wound dehiscence , infection and pain were in 1,6 and 12 months after treatment.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Criteria of bisphosphonate-related Osteonecrosis in stage II * need debridement and surgical intervention Exclusion Criteria: * Malignancy in the area * History of chemotherapy , * diabetic mellitus * HIV * odontogenic infection or undergo dialysis

What they're measuring

Soft tissue healing

Timeframe: After one month

Soft tissue healing

Timeframe: Six months after treatment

Soft tissue healing

Timeframe: 12 months after treatment

Pain

Timeframe: one month after treatment

Pain

Timeframe: Six months after treatment

Trial details

NCT IDNCT03269214

SponsorShiraz University of Medical Sciences

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-10-31

View on ClinicalTrials.gov More Osteonecrosis Due to Drugs, Jaw trials