Effects of Dehydration on Neuromuscular Performance and Sympathetic Control of Cardiovascular Fun… (NCT03263975) | Clinical Trial Compass
CompletedNot Applicable
Effects of Dehydration on Neuromuscular Performance and Sympathetic Control of Cardiovascular Function
43 participantsStarted 2014-10-31
Plain-language summary
The mechanism(s) by which dehydration (both intra- and extracellular) impairs performance are still poorly described. A loss of volume results in increased occurrence of orthostatic intolerance, including dizziness, fatigue, headaches and related symptoms with upright posture. Any of these symptoms can contribute to decreased performance in maneuvers performed in the upright posture, which includes many military tasks. Thus, loss of volume challenges the cardiovascular and blood pressure responses to systemic whole body endurance exercise, while osmolality is the stimulus for intracellular dehydration that may impair local muscle force production by impairing contractile function, neural signaling, or both. In this study, we will compare how both types of dehydration affect MSNA and CAC.
The results of this study will provide mechanistic insight for how dehydration (intra- or extracellular) impairs systemic whole body and local small muscle performance in vivo. This Basic Science study seeks to understand how volume and osmolality impact MSNA and CAC as a basis for improving potential countermeasures, such as a more optimally formulated rehydration beverage. Therefore, this study directly complements Task Area T10 (Hot Weather Operations and Hydration: Injury and Performance Optimization) and impacts virtually all 14 Military Operational Medicine Research Program Drivers.
Who can participate
Age range
18 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male or female, age 18-45
* In good health as determined by OMSO General Medical Clearance
* Passed his/her most recent Army Physical Fitness Test (APFT) (military volunteers only) or exercise at least 2 times per week (civilian volunteers)
* Ability to comprehend and willingness to sign informed consent
Exclusion Criteria:
* Females who are pregnant or planning to become pregnant during the study
* Taking prescription or over the counter medication, other than a contraceptive (unless approved by OMSO and PI)
* Physical problems/injuries associated with walking or cycling
* Allergy to sulfa drugs (Lasix™ or sulfonamide antibiotics such as Septra™)
* Allergy to skin adhesive
* Hemoglobinopathy (sickle cell trait)
* Heart, lung, kidney, muscle, or nerve disorder(s)
* History of heat or orthostatic intolerance
* Diagnosed and/or treated for fluid/electrolyte imbalance within the last 30 days
* Presence of metal implants/electronic medical devices in lower extremities
* Current or previous (within the past 5 years) diagnosis of any autonomic disorder, including idiopathic orthostatic intolerance, orthostatic hypotension, postural tachycardia syndrome (POTS), or neurocardiogenic syncope (MSNA group only)
* Tobacco/nicotine use (MSNA group only)
* Significant muscle, joint, or bone injury affecting the legs within the last 6 months (CAC group only)
* Difficulty swallowing large pills
* History of obstructive disease of the gastrointestinal tract including (…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Water and electrolyte retention
Timeframe: 180 minutes
Trial details
NCT IDNCT03263975
SponsorUnited States Army Research Institute of Environmental Medicine