Targeted AntiBiotics for Chronic Pulmonary Diseases

Inclusion Criteria: * P. aeruginosa-positive lower respiratory tract sample. * COPD, non-CF bronchiectasis, or asthma verified by a respiratory specialist based on clinical assessment and additional tests: COPD: spirometry; Asthma: reversibility; Non-CF bronchiectasis: high-resolution computed tomography scan. * Minimum of two previous exacerbations, or one previous hospitalization-requiring or emergency room-demanding exacerbation, with the treatment of systemic prednisolone and/or antibiotics within the last 12 months. * Written informed consent Exclusion Criteria: * Immune-modulating therapy (except ≤ 10 mg prednisolone/day) * Men \< 40 years * Women \<= 55 years * Non- menopausal women \> 55 years * Life expectancy \< 90 days * Severe mental illness * Severe language difficulties or inability to provide informed consent * Known drug allergy to 1) Fluoroquinolones and 2) both Piperacillin/tazobactam, Cephalosporins and Carbapenems * Attempted eradication of P. aeruginosa x 2 within the last 12months, or completed eradication therapy within the last 14 days * The investigator 's opinion is that the participant requires antibiotic treatment. This exclusion criterion must be discussed with the coordinating investigator before the final decision on exclusion is taken.