LEAn Body Mass Normalization of OXaliplatin Based Chemotherapy

Inclusion Criteria: * Age: more than 18 years old up to 75 years old including. Histologically confirmed adenocarcinoma of the colon. * Has undergone a curative resection for stage III colon cancer. * Scheduled to receive 6 months of Oxaliplatin-based adjuvant chemotherapy at a dose of 85 mg/m² of Oxaliplatin every 2 weeks (simplified FOLFOX 4 regimen). * The following laboratory values obtained ≤ 28 days prior to inclusion: WBC ≥ 3000/mm3; ANC ≥1500/mm3; PLT ≥100,000/mm3; HgB ≥10.0g/dl; Total bilirubin ≤1.5 x upper normal limit (UNL); Serum creatinine ≤1.5 x UNL; Serum calcium ≤ 1.2 x UNL; Serum magnesium ≤ 1.2 x UNL. * Central venous access line present or patient scheduled to have a central line placed prior to starting chemotherapy or the treatment protocol. * Negative pregnancy test (serum or urine) done ≤ 7 days prior to registration, for women of childbearing potential only. * Ability to complete questionnaire(s) by themselves or with assistance. * ECOG Performance Status (PS) of 0, 1 for patients until 70 years old included and ECOG PS of 0 for patients between 70 to 75 years old included. * Has provided informed written consent. * Patient willing to provide blood sample for research purposes * Patient affiliated to a French social security system Exclusion Criteria: * Pregnant or breastfeeding women * Men or women of childbearing potential who are unwilling to employ adequate contraception since this study involves agents that have known genotoxic, mutagenic and…