RecruitingPhase 1/2

Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia

Canada12 participantsStarted 2023-01-01

Plain-language summary

A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).

Who can participate

Age range18 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy adults * 18 - 45 years of age * Living in Calgary for the past one year * Have no medical condition or should not be taking any blood pressure medications. * The participant should not be lactose intolerant Exclusion Criteria: * Cerebrovascular, cardio-respiratory, renal and metabolic diseases * Bleeding disorders and upper gastrointestinal diseases e.g. peptic ulcer disease * Pregnancy, obese and sleep-disordered breathing * Drug allergies to non-steroidal anti-inflammatories * Currently smoking

What they're measuring

Changes in cerebral blood flow and ventilatory chemoreflexes

Timeframe: ~18 months (from the starting time of recruiting study participants)

Cerebral blood flow responses and ventilatory chemoreflexes during sleep

Timeframe: ~18 months (from the starting time of recruiting study participants)

Trial details

NCT IDNCT03255408

SponsorUniversity of Calgary

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-30

View on ClinicalTrials.gov More Obstructive Sleep Apnea of Adult trials