CompletedNot Applicable

Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution

China70 participantsStarted 2017-09-09

Plain-language summary

This study aims to evaluate whether dietary supplementation with fish oil can protect against the cardiopulmonary alterations linked to air pollution

Who can participate

Age range18 Years – 27 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Equal to or older than 18 years old. * No history of smoking and alcohol addiction. * No chronic diseases or respiratory or allergic diseases,such as hypertension,diabetes,chronic obstructive pulmonary disease,other respiratory/cardiovascular diseases, asthma, rhinitis or other allergic diseases reported by volunteers. * No allergies to n-3 PUFA or fish. Exclusion Criteria: * Current smokers or ever smokers * Chronic drug use due on cardiovascular or respiratory diseases * Participants are taking fish oil,anti-inflammatory drugs, or antioxidant supplements (such as vitamin C or vitamin E)

What they're measuring

Biomarkers of Antioxidant Activity-Total Antioxidant Capacity (TAC) and Superoxide Dismutase (SOD)

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Biomarkers of Inflammation-Interleukin-6 (IL-6) and Tumour Necrosis Factor-α (TNF-α)

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Cogulation Biomarker-von Willebrand Factor (vWF)

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Biomarkers of Endothelial Function and Stress Hormone

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Endothelial Function Biomarker-Endothelin-1(ET-1)

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Cogulation Biomarker-Fibrinogen

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Trial details

NCT IDNCT03255187

SponsorFudan University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-01-13

Results submitted2019-10-13

View on ClinicalTrials.gov More Oxidative Stress trials

Who can participate

Age range18 Years – 27 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Biomarkers of Antioxidant Activity-Total Antioxidant Capacity (TAC) and Superoxide Dismutase (SOD)

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Biomarkers of Inflammation-Interleukin-6 (IL-6) and Tumour Necrosis Factor-α (TNF-α)

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Cogulation Biomarker-von Willebrand Factor (vWF)

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Biomarkers of Endothelial Function and Stress Hormone

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Endothelial Function Biomarker-Endothelin-1(ET-1)

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.

Cogulation Biomarker-Fibrinogen

Timeframe: Blood samples are obtained at the end of each round of 4 follow-ups with an interval of 2 weeks in the last 2 months of intervention.