Methotrexate, Blood Pressure and Arterial Function in Rheumatoid Arthritis

Inclusion Criteria: * Patient with rheumatoid arthritis according to EULAR/ACR 2010 criteria. * Age ≥18 years. * Written informed consent, dated and signed before initiating any study-related procedure. Exclusion Criteria: * Contraindication to MTX or sulfasalazine. * Patient who cannot be followed during 6 months. * Active alcohol or substance abuse within the last 12 months. * Participation in a clinical trial within 3 months prior to the start of the study. * Body mass index \>35 Kg/m2. * Secondary causes of hypertension. * Grade 2 (moderate) or 3 (severe) hypertension: clinic blood pressure \>160/100 mm Hg. * Resistant hypertension: clinical blood pressure ≥140/90 mm Hg despite concurrent use of three antihypertensive agents of different classes, one of which is a diuretic. * Clinical systolic blood pressure \<100 mm Hg or history of symptomatic orthostatic hypotension. * Cardiovascular event, procedure, or hospitalization for unstable angina with the last 6 months. * Atrial fibrillation. * Heart failure. * Treatment with nitrates. * Estimated glomerular filtration rate (eGFR) \<45 mL/min. * Diagnosis of polycystic kidney disease. * Glomerulonephritis treated with or likely to be treated with immunosuppressant drugs * Uncontrolled diabetes with HbA1c \>9.0% (\>75 mmol/mol). * Uncontrolled dyslipidaemia with total serum cholesterol \>7.5 mmol/L or triglycerides \>5.6 mmol/L. * Clinical diagnosis of dementia, treatment with medications for dementia or, in the opinion of …