N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes

Inclusion Criteria: * Subject undergoing elective major (above-knee or below-knee) lower extremity amputation for CLI * Both male and female patients * All ethnic groups * Between of the ages of 30-90 years old * Adequate nutritional status - defined as BMI \> 19 Exclusion Criteria: * Pregnant women, and women who are breastfeeding * Known history of end-stage liver disease * Severe asthma * Heavy alcohol consumption (male \> 2 drinks per day and women \> 1 drink per day) * Individuals actively receiving chemotherapy. * Anticipated enrollment in another study that investigates another drug agent within 30 days from enrollment in this study. * Patients receiving carbamazepine. * Severe anemia (HCT \< 22). * Allergy to either NAC or Indocyanine Green (ICG). * Patients with open wound(s) from a prior amputation on the ipsilateral limb (excluding patients who had prior partial foot amputation, who are now requiring a below-knee or above-knee amputation).