RecruitingNot Applicable

Uterus Transplantation From a Multi-organ Donor

Belgium20 participantsStarted 2016-11-03

Plain-language summary

Uterus transplantation: screening, in vitro fertilization \[IVF\] treatment to be able to freeze embryos, uterus transplantation, pregnancy and afterwards removal of the uterus.

Who can participate

Age range18 Years – 38 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Female with Maier-Rokitansky-Kuster-Hauser syndrome * Mucosal neovagina of at least 7 cm * In a stable relationship for at least 1 year * Child wish * Good renal function (and presence of both kidneys) * Psychologically stable and compliant * At least 8 frozen embryos after IVF/intracytoplasmic sperm injection \[ICSI\] * Living in Belgium and a good health insurance * Willing and able to provide informed consent Exclusion Criteria: * Major pelvic surgery * Major chronic illnesses * Other risk factors or malignancies * BMI \> 30

What they're measuring

Survival of the uterus 1 year after transplantation

Timeframe: 1 year after uterus transplantation

Complications after uterus transplantation

Timeframe: As long as the uterus remains in situ (the uterus will be removed within one year after delivery)

Ongoing pregnancy rate

Timeframe: 4 weeks after embryo transfer

Take home baby rate

Timeframe: 9 months after embryo transfer

Trial details

NCT IDNCT03252795

SponsorUniversity Hospital, Ghent

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-31

Contact for this trial

Steven Weyers, MD, PhD

+3293325446 steven.weyers@uzgent.be

View on ClinicalTrials.gov More Infertility, Female trials