Application of Palliative Treatment in Children With Brain Stem Glioma and Recurrent High-grade Tumors in the Central Nervous System With the Nanomaterial NPt-Ca

Inclusion Criteria: * Histopathological diagnosis or MRI of the brain stem or tumor of recurrent high-grade glioma. * Indication of palliative surgical treatment by neurosurgery. * Good general condition, enabling the realization of surgical treatment. * Scale Lansky \> 20) * conventional treatment (surgery, radiotherapy, and chemotherapy) failed or not applicable to the patient. Exclusion Criteria: * Patients with emerging infectious diseases or fever in the last 72 hours prior to placement of the NPt-Ca. * Patients whose parents/carers do not authorize expressly the realization of procedure with knowledge of its experimental nature, are not agreed or established their commitment to meet follow-up parameters established by this Protocol. * Patients with surgical complications prior to placement of the NPt-Ca. * Patients in which the size and location of the lesion do not allow their surgical approach or an increase in volume by infiltration of the lesion with 3 ml of volume of NPt-Ca. * Patient whose neurological condition do not allow the implementation of MRI without anesthesia.