Safety and Effectiveness of Cartiva Implant in the Treatment of First CMC Joint Osteoarthritis Compared to LRTI (GRIP 2)

Inclusion Criteria: * ≥ 22 years of age * Refractory to conservative non-operative standard of care treatment for first CMC OA lasting for at least 6 months that requires surgical intervention * Eaton classification stage II or III OA of the first CMC joint based on X-rays taken within 6 months of the Operative date and evidence of first CMC joint OA based on subjective review of associated clinical symptoms * Preoperative VAS Pain score of ≥ 40 in the treated hand * Preoperative 11 question QuickDASH score of ≥ 20 * Presence of good bone stock - i.e., no need for bone graft * Capable of completing self-administered questionnaires * Be willing and able to return for all study-related follow up procedures * Have been informed of the nature of the study, agreeing to its requirements, and have signed the informed consent approved by the IRB/REB/Ethics Committee Exclusion Criteria: * Active systemic infection * Active infection at the site of surgery * Previous CMC implant, trapeziectomy, or LRTI to the affected joint to be treated * Inflammatory arthropathy and/or diagnosis of grout * History of or current diagnosis of rheumatoid arthritis * Any significant bone loss, avascular necrosis, or cyst \> 8mm of the supporting bone structure * Eaton classification stage IV advanced OA of the first CMC joint based on X-rays taken within 6 months of the Operative date * Physical conditions that would tend to eliminate adequate implant support (e.g., inadequate cortical bone stock of a…