TerminatedPhase 4

Oral Olanzapine Versus Haloperidol or Diazepam

Stopped: The study was terminated prematurely due to difficulties in patient recruitment and associated potential for selection bias.

Hong Kong12 participantsStarted 2017-09-01

Plain-language summary

The purpose of this study is to determine whether oral olanzapine is safer (fewer adverse events) and more effective (shorter time to sedation) than conventional haloperidol or diazepam when used in the management of acute agitation in the emergency.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Accident \& Emergency Department patients * Requiring oral drug sedation (as determined by an emergency clinician) will be enrolled. Exclusion Criteria: * known hypersensitivity or contraindication to the study drugs * reversible aetiology for agitation (e.g. hypotension, hypoxia, hypoglycaemia) * known pregnancy * acute alcohol withdrawal * refusal to take oral medication * patients from correctional facilities

What they're measuring

Time to achieve adequate sedation

Timeframe: Within 60 minutes from drug administration

Trial details

NCT IDNCT03246620

SponsorThe University of Hong Kong

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-06-01

View on ClinicalTrials.gov More Acute Agitation trials