CompletedNot Applicable

Biomarker-guided Implementation of the AKI Bundle

Belgium, Germany280 participantsStarted 2017-11-02

Plain-language summary

There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury. The investigators hypothesize that the implementation of a bundle of supportive measures adapted to patients undergoing cardiovascular surgery reduces the occurence of AKI. A Randomized prospective multicenter trial is needed to investigate whether the implementation of the bundle of measures is effective to prevent AKI in high risk patients undergoing cardiac surgery. In this feasibility trial the investigators will analyze the compliance rate to the trial protocol in a multicenter, multinational cohort in preparation for a large randomized controlled trial.

Who can participate

Age range18 Years – 90 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) * Urinary \[TIMP-2\] \* \[IGFBP7\] \>= 0.3 4h after CPB * Written informed consent Exclusion Criteria: * Preexisting AKI (stage 1 and higher) * Patients with cardiac assist devices (ECMO, LVAD, RVAD, IABP) * Pregnancy, breastfeeding * Known (Glomerulo-)-Nephritis, intersstitial nephritis or vasculitis * CKD with eGFR \< 20 mL/min * Dialyses dependent CKD * Prior kidney transplant within the last 12 months

What they're measuring

Compliance rate

Timeframe: 48 hours after start of intervention

Trial details

NCT IDNCT03244514

SponsorUniversity Hospital Muenster

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-10-26

View on ClinicalTrials.gov More Acute Kidney Injury (Nontraumatic) trials