This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.
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Change in ganglion cell-inner plexiform layer (GCIPL) thickness
Timeframe: Baseline, 1 year
Change in retinal nerve fiber layer (RNFL) thickness
Timeframe: Baseline, 1 year
Change in central subfield thickness (CST)
Timeframe: Baseline, 1 year
Change in choroidal vascularity index (CVI)
Timeframe: Baseline, 1 year
Change in foveal avascular zone (FAZ) area
Timeframe: Baseline, 1 year
Change in average perfusion density (PD)
Timeframe: Baseline, 1 year
Change in average vessel density (VD)
Timeframe: Baseline, 1 year
Change in average capillary perfusion density (CPD)
Timeframe: Baseline, 1 year
Change in average capillary flux index (CFI)
Timeframe: Baseline, 1 year