Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis

Inclusion Criteria: * Subjects \> 18 yrs of age Willing to give appropriate informed consent Presence of corneal ulcer measuring \> 2mm in vertical and horizontal dimensions at presentation (epithelial defect and signs of stromal inflammation) Microbiologic evidence of fungus on smear and or culture media Willing to return for all the follow up visits Exclusion Criteria: * Patients not willing to give consent Patients unable to cooperate for the procedure Patient with impending, or actual perforation or bilateral corneal ulcer or scleral involvement History of previous ocular surgery Evidence of bacterial, parasitic or viral infection or co-infection Previous corneal scar Known allergy to the study medication (drug or preservative) Pregnant or nursing females Immunocompromised patients