Comparing Efficacy and Safety of CinnaGen Biosimilar Growth Hormone (CinnaTropin®) Versus Nordilet in Children With Idiopathic Growth Hormone Deficiency

Inclusion Criteria: * • Pre-pubertal boys and girls between 4-16 years (Tanner's stage 1) * Height Standard Deviation Score (HSDS) ≤ -2 SD for chronological age (Brandt/Reinken) * Approved GH Deficiency following clonidine GH stimulation test (150 µg/ m2, up to a maximum of 0.2 mg), and determining GH levels at 0, 30, 60, 90, and 120 minutes. This test is performed by overnight fasting and considered positive if GH ≥ 10 ng/ml, otherwise GHD is relevant. * Ruling out of other causes of short stature (hypothyroidism, Celiac disease, and etc.) * Documented Pituitary or hypothalamic hormone deficiency and below normal serum IGF-1 at the time of diagnosis * In case of the deficiency in other pituitary hormones, the patient can only be included, if the replacement of other pituitary hormones was done, and this is determined by the replacement of glucocorticoids provided that no symptoms of Cushing's syndrome be present, and the replacement of thyroxine and reaching to normal levels of free T4 and free T3. Exclusion Criteria: * • Any Illness that prevent the proper conduct of the trial, such as seizure, acute or systemic infectious disease in the past 6 months, chronic pulmonary infection, AIDS, chronic liver disease (verified disease of the hepatic cells or 2-fold or more increase in liver enzymes) * Any active malignancy (such as leukemia, etc.), * Contraindications of the administration of growth hormone (sleep apnea syndrome) * Turner syndrome. * Short sta…