CompletedNot Applicable

Cardiac Rehabilitation in Patients With Refractory Angina

Brazil72 participantsStarted 2016-01-01

Plain-language summary

The purpose of this study is to evaluate the safety and feasibility of cardiovascular rehabilitation in Patients with refractory angina, evaluate the effect of cardiovascular rehabilitation in patients with angina Refractory, by maximal oxygen consumption (VO2max) and global myocardial ischemic load by Stress Echocardiography; To evaluate the presence of myocardial injury, caused by physical stress, through ultra-sensitive troponin after sessions of aerobic physical activity, evaluating the behavior during the training period; To evaluate the effect of rehabilitation on the modulation of sympathetic activity and inflammation, muscular blood flow and lipid metabolism; To evaluate of the effect of rehabilitation on ventricular function through Stress echocardiography; Detection of ischemic episodes and arrhythmias identified during the Rehabilitation sessions through external cardiac monitoring (telemetry); Evaluate the quality of life assessment through the SF-36 questionnaire, Canadian Cardiovascular Society, the number of symptomatic episodes of ischemia, daily sublingual nitrate intake.

Who can participate

Age range45 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Group 1 and 2 Inclusion Criteria: * Stable angina functional class II to IV according to the classification of Canadian Cardiovascular Society (CCS) 39, or limiting angina in Perception of the patient; * Documented myocardial ischemia by imaging method; * Patients not eligible for myocardial revascularization procedures surgical conventional, due to the unfavorable anatomy; * Signature of the Free and Informed Consent Form. Exclusion Criteria: * Patients with definitive pacemaker or implantable cardioverter defibrillator (ICD); * Patients with non-sinus heart rhythm; * Patients with complete intraventricular block; * Acute coronary syndrome (myocardial infarction or unstable angina) or previous procedures for myocardial revascularization (angioplasty / surgery) less than 3 months; * Functional impossibility (orthopedic, rheumatic, neurological, or otherwise) or social for participation in the Rehabilitation Program; * Classification of risk for American Heart Association class D physical training (unstable ischemia, stenosis or severe or symptomatic valve insufficiency, congenital heart disease, decompensated heart failure, uncontrolled arrhythmias and other conditions that may be aggravated by exercise). Group 3 Inclusion Criteria: * Patients with coronary insufficiency without angina; * Signature of the Free and Informed Consent Form. Group 4 Inclusion Criteria: * Signature of the Free and Informed Consent Form; * Healthy; * Non-smokers; * Sedentary

What they're measuring

Cardiovascular rehabilitation in patients with refractory angina is safe;

Timeframe: 3 months of rehabilitation

Cardiovascular rehabilitation in patients with refractory angina is efficient;

Timeframe: 3 months of rehabilitation

Improve the maximal oxygen consumption

Timeframe: 3 months of rehabilitation

Improve the global myocardial ischemic load

Timeframe: 3 months of rehabilitation

Trial details

NCT IDNCT03218891

SponsorHospital Israelita Albert Einstein

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-07-28

View on ClinicalTrials.gov More Refractory Angina trials

Plain-language summary

Who can participate

Age range45 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Cardiovascular rehabilitation in patients with refractory angina is safe;

Timeframe: 3 months of rehabilitation

Cardiovascular rehabilitation in patients with refractory angina is efficient;

Timeframe: 3 months of rehabilitation

Improve the maximal oxygen consumption

Timeframe: 3 months of rehabilitation

Improve the global myocardial ischemic load

Timeframe: 3 months of rehabilitation