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Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis

China100 participantsStarted 2017-07-20

Plain-language summary

The purpose of the study is to learn if adding femtosecond laser-assisted corneal debridement to a standard therapy of oral ganciclovir can help shorten the healing time of herpes simplex epithelial keratitis (HSK).

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Aged between 18 and 80 years old;
✓. Epithelial ulceration in a dendritic or geographic pattern, characteristic of infection with herpes simplex virus, and within 7 days of onset;
✓. Ulcer's stromal involvement \< 120 micron, as indicated by anterior segment optical coherence tomography;
✓. Informed consent signed by patient or legal guardian. Having the ability to comply with study assessments for the full duration of the study.

Exclusion criteria

✕. Clinical signs of a cause other than herpes simplex virus for the epithelial keratitis;
✕. Antivirus or corticosteroid treatment within 6 months;
✕. Active stromal keratitis or iritis;
✕. History of allergy or adverse reaction to ganciclovir;
✕. High myopia with a spherical equivalent of -15.0 D or less;
✕. Corneal or ocular surface infection within 30 days prior to study entry;
✕. Ocular surface malignancy;
✕. Uncontrolled diabetes with most recent Hemoglobin A1c greater than 8.5%;

What they're measuring

Healing time

Timeframe: 14 ± 1 days

Trial details

NCT IDNCT03217474

SponsorChunxiao Wang

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-12-30

Contact for this trial

Yingfeng Zheng, M.D.Ph.D.

+8613922286455 yingfeng.zheng@qq.com

View on ClinicalTrials.gov More Herpes Simplex Keratitis trials