Evaluation of Vascular Regeneration After a Drug Eluting Stent Implantation

Inclusion Criteria: * Patients who present stable angina, silent ischemia or unstable angina whenever there is no elevation of markers of myocardial damage above the limit of normality * Presence of at least one severe coronary stenosis (\> 70% by visual analysis), susceptible of percutaneous treatment with stent implantation and an optical coherence Tomography study * All patients should be taking statins at least 2 months prior to their inclusion in the study. Exclusion Criteria: * Age under 18 years and pregnant or fertile age, * Patients with ST-elevation myocardial infarction or non-ST-elevation acute coronary syndrome with markers of recent myocardial damage (\<3 months), * Patients in whom a drug-eluting stent and a bare stent have been implanted in the same procedure. * Percutaneous treatment of restenotic lesions or total chronic occlusions. * The use of stent pre-implantation ablation techniques (rotablator, directional atherectomy). * Chronic renal insufficiency with serum creatinine greater than or equal to 2.5. * Coronary revascularization in previous 3 months. * Severe ventricular dysfunction (\<25%). * Major trauma or surgery in the previous 3 months. * Previous organ transplantation, active neoplastic process or inflammatory disease, treatment with immunosuppressors. * Contraindication or allergy to thienopyridines. * Life expectancy less than one year.