Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.

Inclusion Criteria: * Healthy volunteers :dated and signed written consent * Primary Raynaud's patients : * dated and signed written consent * subject presenting a primary Raynaud's phenomenon non associated to a connectivite. RP crisis are defined by a succession of caracteristic symptoms : a syncopal phase with distal whitening of the fingers, usually followed by a cyanotic phase, and then a hyperhemic phase with the outbreak of painful redness.The syncopal phase is always present, while the two other phases can be less pronounced, or even absent. * Sclerodermy secondary Raynaud's patients : * dated and signed written consent * subject with Raynaud's phenomenon secondary to systemic sclerosis, according to the 2013 EULAR/ACR criteria. Exclusion Criteria: * Minor person or major person protected by the law * Exclusion period for any clinical trial including a medication or focusing on a clinical device linked to the pathology * Social secutrity scheme non-affiliated person or person who cannot pretend to such a scheme * Pregnant woman, parturient or breast-feeding mother * Person displaying a digital ulcer or a history of digital ulcer * Severe concurrent disease found at oral questioning : evolutive cancer, hepatic insufficiency, history of myocardic infarction in the past five years, angina pectoris * Hemodynamic instability * Any tobacco consumption * Any contraindication to the medication used in this trial : * Anesderm ® (lidocain/procain) : Known hypersensitivity, t…