CompletedNot Applicable

Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

France204 participantsStarted 2017-04-13

Plain-language summary

Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who have provided explicit consent * Patients older than 18 years * Patients about to undergo surgery for carotid stenosis * Haemoglobin ≥ 7g/dl at the time the sample is taken * Respect the maximum volume of blood taken (treatment + research) in 30 days SPECIFIC TO DIABETICS \- Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier Exclusion Criteria: * Patients under guardianship * Patients without health insurance cover * Pregnant or breast-feeding women

What they're measuring

Change in arachidonic acid metabolism of atheromatous plaques from diabetic versus non-diabetic subjects

Timeframe: Baseline

Trial details

NCT IDNCT03202823

SponsorCentre Hospitalier Universitaire Dijon

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-12-11

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