Use of Biopsies of Abdominal Subcutaneous Fat to Study the Role of the Activation of Endocannabin… (NCT03202706) | Clinical Trial Compass
CompletedNot Applicable
Use of Biopsies of Abdominal Subcutaneous Fat to Study the Role of the Activation of Endocannabinoid 1 Receptors (CB1R) on Adipocyte Glucolipid Metabolism
France51 participantsStarted 2016-02-24
Plain-language summary
Obesity is associated with hyperactivation of the endocannabinoid system, and its inhibition by the administration of CB1 receptor (CB1R) antagonists, leads to a decrease in food intake, weight loss and an improvement in metabolic parameters. Even though the reduction in food intake following central CB1R inactivation seems to be the principal cause of weight loss and the improvement in metabolic parameters, several studies in animals and humans have indicated that peripheral CB1R could also be implicated in the regulation of glucolipid metabolism. As a result, it has been suggested that the long-term beneficial effects of inactivation of the endocannabinoid system are due to both central effects on food intake and peripheral effects involving adipose tissue, the liver, skeletal muscle and the pancreas. It appears essential to determine the role of CB1R located in peripheral tissues and in particular in adipose tissue, which plays an active role in maintaining glucolipid homeostasis. The experiments conducted in this project consist in studying in biopsies of abdominal subcutaneous fat whether activation of adipocyte CB1R modifies adipocyte metabolism by determining the mechanisms. The investigators hypothesize that activation of CB1R in adipose tissue will lead to the stimulation of lipolysis dependent on the alteration of the insulin signal, and therefore that inactivation of the endocannabinoid system by blocking peripheral CB1R could constitute a therapeutic approach to improve obesity-related insulin resistance and dyslipidaemia.
Who can participate
Age range
18 Years – 70 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
healthy subjects
Inclusion Criteria:
* men aged 18 to 70 years
* persons who have provided oral consent
* persons undergoing surgery for hernia
Exclusion Criteria:
* persons without health insurance cover
* BMI \> 30
* diabetes
* associated diseases: cancer, chronic inflammatory diseases
* adults under guardianship
obese subjects
Inclusion Criteria:
* men aged 18 to 70 years
* BMI \> 30
* persons who have provided oral consent
* persons undergoing surgery for hernia
Exclusion Criteria:
* persons without health insurance cover
* diabetes
* associated diseases: cancer, chronic inflammatory diseases
* adults under guardianship
diabetic obese subjects
Inclusion Criteria:
* men aged 18 to 70 years
* type 2 diabetic not treated with Insulin or GLP-1 agonist
* BMI \> 30
* persons who have provided oral consent
* persons undergoing surgery for hernia
Exclusion Criteria:
* persons without health insurance cover
* associated diseases: cancer, chronic inflammatory diseases
* adults under guardianship
Questions worth asking your doctor
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1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
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Questions for the trial coordinator
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1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Glucolipid metabolism analysis in human abdominal subcutaneous and visceral fat