TerminatedNot Applicable

NK Cell Mediated Influenza Immunity During Pregnancy

United States94 participantsStarted 2012-08-14

Plain-language summary

Pregnant women have increased morbidity and mortality due to infection with influenza. Changes in T cell function have been proposed as possible mechanisms for this finding. We believe that pregnancy induced changes in NK cell phenotype and function also impact influenza immunity. This study will compare the immune response of pregnant women and controls to TIV influenza vaccination as a surrogate for infection. In addition pregnant women with flu like illness will be enrolled to evaluate changes in immune response following influenza infection as compared to vaccination.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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Inclusion Criteria: * Pregnant women (18-42 years of age) * Pregnant women planning to receive the TIV seasonal influenza vaccine or Pregnant women presenting with influenza like illness Exclusion Criteria: * Oral immunosuppressive agents (inhaled steroids OK) * Serious chronic illness including autoimmune disease or chronic viral infections (eg, systemic lupus erythematosis,HIV, hepatitis B or C) * Malignancy or blood dyscrasia * Type I or II diabetes or morbid obesity (pre-pregnancy BMI\>40)(gestational diabetes ok) * Presence of fetal cardiac abnormalities * Receipt of blood or blood products within the last year * Prior receipt of current seasonal influenza vaccine for influenza vaccine arm * History of egg allergy for influenza vaccine arm

What they're measuring

NK cell function

Timeframe: 2 years

Trial details

NCT IDNCT03196245

SponsorStanford University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-04-01

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