Type 2 diabetes mellitus (T2DM) patients from our previous survey tend to co-administer various herbs with their oral hypoglycemic agents (OHA). Some of these herbs are known to possess antidiabetic activities. One of such is Moringa oleifera leaves. The present study evaluated the effects of seven days, twice-daily administration of hot water infusion of dried Moringa oleifera leaves on the steady state plasma concentrations of Metformin, one of the most widely used OHAs using T2DM patients who have been on Metformin for a period of not less than three months. The included patients had also been on Moringa supplementation but had terminated the use of Moringa at least a month to the start of the study. Patients who had other comorbidities such as heart diseases, renal or hepatic impairments were excluded from the study. The patients were recruited from Endocriniology clinic of the Obafemi Awolowo University Teaching Hospitals complex, a tertiary hospital from southwest Nigeria. Each patient served as his/her control.
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Change in Fasting Blood Glucose
Timeframe: Change from Baseline Fasting Blood Glucose at 1 week
Change in Two-hour Post Prandial Blood Glucose
Timeframe: Change from Baseline Two-hour Post Prandial Blood Glucose at 1 week
Change in metformin trough plasma concentration
Timeframe: Change in metformin trough concentration at 1 week
Change in metformin peak plasma concentration
Timeframe: Change in metformin peak concentration at 1 week
Change in estimated glomerular filtration rate
Timeframe: Change in estimated glomerular filtration rate at 1 week