CompletedPhase 4

Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso

United States, Burkina Faso252 participantsStarted 2017-07-04

Plain-language summary

The use of antibiotics has saved millions of human lives, however consumption of antibiotics can select for antibiotic resistant organisms and may lead to changes in commensal microbiome. This study is designed to estimate the effect of antibiotic consumption on microbiome in a rural region of rural Burkina Faso. Changes in the intestinal and nasopharyngeal microbiome and resistome following a short course of antibiotics will be measured.

Who can participate

Age range6 Months – 59 Months

SexALL

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Inclusion Criteria: * Households will be eligible for inclusion in the study if they have 2 or more children aged 6 months to 59 months currently residing in the household. Children from the household will be eligible if they are 6-59 months of age and are not currently receiving antibiotic treatment Exclusion Criteria: * Children who are allergic to any of the study antibiotics will be excluded. Individuals aged under 6 months and 5 years or older will be excluded. Children already receiving antibiotics for an ongoing disease will be excluded.

What they're measuring

Simpson's Index of Diversity (Alpha Diversity) in Intestinal Microbiome

Timeframe: Baseline and Day 9

Trial details

NCT IDNCT03187834

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-09-01

Results submitted2021-09-17

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