WithdrawnNot Applicable

Natural History of Granulomatosis With Polyangiitis: Clinical and Genetic Biomarkers of Airway Disease NoAAC PR-03 Study

Stopped: Funding was not able to be secured for the study and no participants enrolled.

United States0Started 2020-12

Plain-language summary

The ultimate goal of this prospective natural history study is to define the natural history of the obstructive airway manifestations of Granulomatosis with polyangiitis (GPA). Additionally this proposal seeks to develop biomarkers of disease activity and define their correlation with clinical outcomes in an effort to transform clinical care and shape future drug development for this devastating rare disease.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Greater than or equal to 18 years of age. * Stenotic Airway Disease (laryngeal, subglottic, distal tracheal or bronchial) Exclusion Criteria: * \<18years of age * Patients without capacity to consent for themselves * History of significant laryngotracheal traumatic injury. * Endotracheal intubation 2 years prior to presentation. * Major anterior neck surgery. * History of neck irradiation. * History of caustic or thermal injury to the laryngotracheal complex.

What they're measuring

Time to recurrent intervention (TTR)

Timeframe: 5 years

Trial details

NCT IDNCT03182049

SponsorVanderbilt University Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-05

View on ClinicalTrials.gov More Granulomatosis With Polyangiitis trials