Multi OIT to Test Immune Markers After Minimum Maintenance Dose

Inclusion Criteria: * Aged 2 to 25 years with clinical history of allergy to at least two of the following: milk and/or egg and/or peanut and/or almond and/or wheat and/or cashew and/or sesame seed and/or soy and/or pecan and/or walnut and/or hazelnut and/or shrimp and/or cod and/or salmon and * Sensitivity to food allergens documented by a positive skin prick test result greater than or equal to 6mm wheal diameter to each allergen or * ImmunoCAP IgE level \>4kU/L for each allergen and * If female of child bearing potential, a negative urine pregnancy test before being allowed to participate in the study (week 0) and * A plan to remain in the study area of the research center during the trial and * Be trained on the proper use of the Epinephrine autoinjector and agree to follow epi training to be allowed to enroll in the study and * If female of child-bearing potential, willing to be compliant with a medically-approved method of contraception (please see Pregnancy section in this IND document) and * Agree to eliminate other known food allergens from subject's diet so as not to confound the safety and efficacy data from the study and * Avoid open or blinded food challenges to food allergens Exclusion Criteria: * Previous anaphylactic reaction to Omalizumab * A history of severe anaphylaxis to food allergens that will be desensitized in this study requiring intubation or admission to an ICU, frequent allergic or non-allergic urticaria, or history consistent with poorly contr…