Inovium Ovarian Rejuvenation Trials

Inclusion Criteria: * Signed and dated informed consent * Women over the age of 35 * Primary or secondary amenorrhea at least for 3-6 months * Presence of at least one ovary * Agree to report any pregnancy to the research staff immediately. * Willing and able to comply with study requirements. * Willing to receive IVF to get pregnant as part of the experimental protocol. Exclusion Criteria: * Men will be excluded from the study. * Current or previous IgA deficiency * Current or previous premature ovarian failure due to a genetic origin, such as Turner's Syndrome or chromosomal abnormality * Current or previous great injuries or adhesions to the pelvis or ovaries * Current and ongoing pregnancy * Current and ongoing anticoagulant use for which plasma infusion appears contraindicated * Current and ongoing major Mental health disorder that precludes participation in the study * Current and ongoing active substance abuse or dependence * Current and ongoing gynecological or non-gynecological cancer * Current and ongoing chronic pelvic pain