Correlation Between Intestinal Microbiota, Inflamatory Biomarkers, Intestinal Morphology, Hepatic Fibrosis Degree and Vascular Reactivity.
46 participantsStarted 2015-01-05
Plain-language summary
Metabolic, inflammatory status, intestinal permeability biomarkers, and gut microbiota composition were investigated in individuals with varying levels of adiposity and glucose tolerance. This project focuses on exploring the associations between gut permeability and metabolic profiles.
Who can participate
Age range18 Years – 50 Years
SexALL
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Inclusion Criteria:
* Healthy men or women between 18 and 50 years old
* Individuals with obesity and normoglycemia
* Individuals with obesity and dysglycemia
Exclusion Criteria:
* Acute disease
* Chronic pulmonary, cardiovascular, haematological, gastrointestinal, hepatic or renal diseases;
* Unstable dietary history, defined as major changes in diet during the previous month diagnosed by a specialist nutritionist;
* History of gastrointestinal disturbances in activity or chronic diseases, including - inflammatory bowel diseases (IBD), chronic diarrhea of unknown etiology, chronic constipation, disabsorbing syndromes,
* History of major gastrointestinal tract surgery, except cholecystectomy and appendectomy;
* Use of the following medications: probiotics in the last 6 months, systemic antibiotics, oral corticosteroids, cytokines, methotrexate or cytotoxic immunosuppressive agents, consumption of large doses of commercial probiotics (greater than or equal to 10 8 CFU or organisms per day)
* Positive tests for HIV infection and hepatitis B and C;
* Pregnant and lactating women;
* Smokers
* Chronic alcoholism.