CompletedPhase 4

PPIs and Gastroesophageal Varices in Liver Cirrhosis (PPIs: Proton Pump Inhibitors)

China106 participantsStarted 2017-05-01

Plain-language summary

This study is aimed at investigating the effect of PPIs on gastroesophageal varices in liver cirrhosis. Half of participants will receive PPI, while the other half will receive a placebo.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Clinical diagnosis of cirrhosis * GEVs was diagnosed by endoscopy Exclusion Criteria: * Acute gastrointestinal bleeding need emergency surgery * Acid-related disease, such as peptic ulcer disease or gastroesophageal reflux diseases (GERD) * Hepatocellular carcinoma (HCC) or other malignant tumor * History of esophagus, stomach or liver surgery * Child-Pugh C and can't be improved to Child-Pugh A or B * Preparing to be pregnant, pregnant or breast feeding * Allergic to PPIs(proton pump inhibitors) or intolerable * Cannot provide informed consent

What they're measuring

Variceal Bleeding Events

Timeframe: 8 weeks

Trial details

NCT IDNCT03175731

SponsorYanjing Gao

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-08-30

Results submitted2021-05-13

View on ClinicalTrials.gov More Liver Cirrhosis trials