Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB

Inclusion Criteria: * New or recurrent pulmonary TB with one or both of the following: * sputum positive for acid-fast bacilli on direct microscopy of at least grade 1+ (International Union Against Tuberculosis and Lung Disease (IUATLD) scale) on at least one pre-treatment sputum sample * sputum positive for M. tuberculosis by Xpert® MTB/RIF testing, with semiquantitative result of 'medium' or 'high' on at least one pre-treatment sputum sample * Age ≥18 and ≤65 years at study screening * Ability and willingness to provide informed consent * Body weight 40 kg to 90 kg, inclusive * Laboratory values obtained within 30 days prior to or at study screening: * Absolute neutrophil count (ANC) \> 750 cells/mm3 * Hemoglobin 7.0 g/dL * Platelet count 50,000/mm3 * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 X upper limit of normal (ULN) * Total bilirubin ≤ 2.5 X ULN * Creatinine \< 1.5 X ULN * HIV infection must be documented as either absent or present * For HIV-positive candidates only: CD4+ cell count of ≥ 100 cells/cu mm, performed within 30 days prior to or at study screening * For females of reproductive potential, negative serum or urine pregnancy test within 7 days prior to or at study screening. Female participants who are participating in sexual activity that could lead to pregnancy must agree to use one reliable non-hormonal method of contraception (condoms or an IUD), or another method (diaphragm or cervical cap) if it is approved by the national…