TerminatedNot Applicable

S. Aureus Decolonization in HPN Patients.

Stopped: Results interim-analysis

Denmark, Netherlands63 participantsStarted 2018-02-08

Plain-language summary

This trial focusses on identifying the most effective and safe long-term S. aureus carriage decolonization strategy in home parenteral nutrition patients. Half of the participants will receive a quick and short systemic antibiotic treatment combined with topical treatment, while the other half will receive only topical treatment on a periodic basis.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient is fully able to understand the nature of the proposed intervention. * Written informed consent by the patient before entering the trial. * Age ≥ 18 years. * Estimated life expectancy ≥ 1 year. * Patient colonized with S. aureus. Exclusion Criteria: * Cannot be expected to comply with the trial plan (substance abuse, mental condition). * Pregnant or breastfeeding women. * Continuous exposure to Methicillin-resistant S. aureus (MRSA; e.g. pig farmer). * Allergy for chlorhexidine and betadine. * No options for oral and/or topical antibiotics due to allergies. * Active S. aureus infection. * Currently on treatment with antibiotics active against S. aureus. * Decolonization (including mupirocin) treatment in the previous two months. * The presence of a nasal foreign body. * Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) levels more than five times the upper limit of normal or liver failure.

What they're measuring

Proportion of patients totally eradicated for S. aureus during one year

Timeframe: One year

Trial details

NCT IDNCT03173053

SponsorRadboud University Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-10-14

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