CompletedPhase 4

Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy

Denmark23 participantsStarted 2017-06-22

Plain-language summary

Investigate serial plasma samples of fibroblast growth factor 19 (FGF19) after oral stimulation with chenodeoxycholic acid in the same subjects before and after elective cholecystectomy

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * planned elective cholecystectomy Exclusion Criteria: * small bowel resection * right sided hemicolectomy * known chronic diarrheal disease (celiac disease, lactose malabsorption, Inflammatory bowel diseases, incl microscopic colitis) * pregnancy * wish for pregnancy within next three months * allergy to eggs * allergy to constituents in Xenbilox (capsules with chenodeoxycholic acid) * acute cholecystitis within two months * chronic cholecystitis * cirrhosis of the liver * suspected obstructive choledocholithiasis * icterus

What they're measuring

Change in Stimulated Fibroblast Growth Factor 19 (FGF19) From Baseline Before Versus Post Cholecystectomy

Timeframe: baseline and 3 - 5 months after cholecystectomy

Trial details

NCT IDNCT03168555

SponsorZealand University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-05-15

Results submitted2021-06-08

View on ClinicalTrials.gov More Bile Acid Malabsorption trials