WithdrawnPhase 4

Early Intrapleural TPA Instillation Versus Late

Stopped: lack of adequate recruitment

United States0Started 2017-02-17

Plain-language summary

Chest tubes are used for air or fluid removal from the pleural space. When a chest tube is placed, it can be hard for the fluid to drain.Tissue plasminogen activator (tPA) and DNase are given through the chest tube to help with draining the fluid. We are doing this research to see if early addition of tPA-DNase immediately after chest tube placement will help with better fluid draining.

Who can participate

Age range18 Years – 100 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients, age 18 years or older * Patients with an indication for a thoracostomy tube placement for a pleural effusion Exclusion Criteria: * Patients that require a thoracostomy tube for a pneumothorax * Pregnant women * Sensitivity to t-PA, or DNase * Patients taking carbamazepine or nitroglycerin * Lung volume reduction surgery on side of pleural effusion

What they're measuring

Chest tube removal

Timeframe: 7 days

Trial details

NCT IDNCT03167281

SponsorPrisma Health-Midlands

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-03-10

View on ClinicalTrials.gov More Tissue Plasminogen Activator trials