Clinical Evaluation of the Performance of a Difluoroethane-based Cyto-selective Cryotherapy to Treat Dark Spots on the Hand in 30 Volunteers.

Inclusion Criteria: * Phototype II to IV * Subjects having brown spots (solar lentigo) on both hands, diameter ≤ 6 mm (at least 1 spot per hand). * Accepting not to expose themselves to the sun (or artificial UV) during the study. * Affiliated to a health insurance scheme in accordance with the French law on research involving the human subjects * Informed, having undergone a general medical examination attesting to his / her ability to participate in the study. * Having given informed written consent for their participation in the study. Non inclusion Criteria: * Having carried out aesthetic care (exfoliants, scrubs or self-tanning, manicure, hand care, UV ...) in the month prior to the start of the study, on the hands. * Having applied a depigmenting product in the month prior to the start of the study, on the hands. * Having carried out aesthetic care at a dermatologist (laser, IPL, peeling, depigmenting creams, cryotherapy ...), on the hands, during the last 6 months. * Presenting dermatosis, autoimmune disease, systemic, chronic or acute illness, or any other condition that may interfere with the treatment or influence the results of the study (diabetic, circulatory, cold allergic, Raynaud's syndrome ...) * Any general or local treatment (dermocorticoids, corticosteroids, diuretics, etc.) likely to interfere with the evaluation of the parameter studied. * Participating in another study or being in an exclusion period from a previous study * Being unable to comply to t…