Propranolol Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery (NCT03152786) | Clinical Trial Compass
TerminatedPhase 2
Propranolol Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery
Stopped: PIs not interested in continuing with the trial.
United States46 participantsStarted 2019-01-15
Plain-language summary
This randomized pilot clinical trial studies how well propranolol hydrochloride works in treating patients with prostate cancer who are undergoing surgery. When stressed, the body makes a molecule that may prevent tumor cells from dying, and propranolol hydrochloride may affect the signals in cells that cause tumor cells survival and death.
Who can participate
Age range
19 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis of prostate cancer undergoing prostatectomy
* Individuals able to understand and willing to sign an Institutional Review Board (IRB)-approved informed consent document
Exclusion Criteria:
* Men taking propranolol on a daily for any reason are excluded
* Men with baseline systolic blood pressure (SBP) \< 110 or heart rate (HR) \< 60
* Men unable to swallow pills
* History of current or past medical or psychiatric illness that would make participation difficult or not feasible at the discretion of the principal investigator or co-investigators
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was terminated before it completed — do you know why it was stopped, and does that affect whether the findings are trustworthy or useful for my situation?
2The trial was testing propranolol, which is a blood pressure medication, in prostate cancer patients before surgery — is there any evidence from this or similar studies that propranolol might have a meaningful effect on prostate cancer, and would it ever be worth considering in my case?
3The main thing this trial was measuring was something called CREB phosphorylation — can you explain what that is in plain terms, and why it might matter for how my prostate cancer behaves or responds to treatment?
4Since this was a Phase 2 trial that was terminated, does that mean there's still a lot we don't know about whether this approach is safe or effective, and are there other active trials I might be a better candidate for?
5Would my standard surgical treatment plan be a better first step right now rather than looking into terminated or experimental options like this one?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean Level of CREB Phosphorylation
Timeframe: 2 hours after taking or not taking propranolol prior to prostatectomy