WithdrawnNot Applicable

Visual Functional Connectivity and Visual Improvement After TMS/Binocular Treatment

Stopped: The study was terminated during COVID as the testing and treatment centres were closed.

Canada0Started 2014-01-30

Plain-language summary

The purpose of this study is to assess the effectiveness of combining binocular treatment with repetitive transcranial magnetic stimulation (rTMS) in improving the vision of adults with amblyopia. This study also seeks to assess the effect of this combined treatment on cortical neural function and functional connectivity.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * A total of 20 strabismic or mixed amblyopic adult patients (eighteen or older) will be recruited from Dr. Mansouri's practice. Patients will be asked for their permission to be contacted by a research assistant with regard to the study. A research assistant will then contact patients and inform them about the study, its procedures, and its voluntary nature. Patients will not be contacted without their previous permission. Exclusion Criteria: * Given the use of rTMS and MRI in this study, participants will be excluded if they have any contraindications to these procedures. Contraindications include: the presence of metal clips or implants in the body (such as pacemakers, defibrillators or neural stimulators), metallic dental work, severe claustrophobia, epilepsy, a family history of seizures, or the taking of epileptogenic medications. Pregnant individuals will also be excluded as a precaution.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Improvement of visual acuity in amblyopic eyes after TMS/binocular treatment

Timeframe: 2 weeks treatment

Trial details

NCT IDNCT03151200

SponsorUniversity of Manitoba

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-12

View on ClinicalTrials.gov More Amblyopia trials