CompletedNot Applicable

EURopean Study on Encephalitis in Intensive CAre

Austria, France, India596 participantsStarted 2017-06-01

Plain-language summary

Prospective observational multicenter study in European ICUs. All patients admitted to the ICU for probable or confirmed Acute encephalitis (2013 IDSA - Infectious Disease Society of America criteria) will be included. Factors associated with a poor prognosis will be identified by multivariate analysis using a logistic regression.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * non-opposition to participate in the study (or consent if applicable according to local legislation) * Impaired consciousness (altered mentation, stupor, or personality changes) for a duration ≥ 24 h, without obvious explanation * A score on the Glasgow Coma Scale \< or =13 at ICU admission * A Cerebrospinal fluid pleocytosis \> = 5 cell / mm3 * At least 2 of the following : * Fever (≥ 38.0 °C) within 72 hours before or after admission * Generalized or partial seizures non-attributable to pre-existing epilepsy * New onset focal neurological deficit * Parenchymal abnormalities on MRI compatible with AE * EEG alterations compatible with AE. Exclusion Criteria: * CSF or neuroimaging not available (s) or not performed. * febrile encephalopathy associated with another diagnosis (sepsis, neurological disease with aspiration pneumonia ... )

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Modified Rankin scale score

Timeframe: Day 90

Trial details

NCT IDNCT03144570

SponsorICUREsearch

Sponsor typeINDUSTRY

Study typeOBSERVATIONAL

Primary completion2020-07-06

View on ClinicalTrials.gov More Encephalitis trials