Efficacy in Daily Use of a Novel Skin Care Product for the Treatment of Photoaged Skin

Inclusion Criteria: * Have moderate to severe photoaging of facial skin (grade 6 or above on the Griffiths scale); * Willing to submit to examination of facial skin, hands and forearms; * Willing to submit to self-treatment with product or placebo cream on face, hands and forearms, including wrists and extensor forearms, for 6 months; * Willing to submit to clinical photography; * Willing to submit to 3 mm punch biopsies from the wrist at beginning and end of trial; * Signed informed consent. Exclusion Criteria: * Skin disease that would impair evaluation of the test sites; * Topical or systemic retinoid within the past 6 months and 12 months respectively prior to entry to the study; * Topical steroid or other topical drugs at treatment sites for at least two weeks prior to study entry; * History of use of experimental drug or experimental device in the 30 days prior to entry into the study; * Any significant cosmetic treatment for skin rejuvenation i.e. dermabrasion, chemical peels, face-lifts; * Known allergy to any of the product or placebo ingredients; * History of keloid scars.