CompletedPhase 4

Mupirocin-Iodophor ICU Decolonization Swap Out Trial

United States353,323 participantsStarted 2017-05-01

Plain-language summary

The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the non-inferiority of two decolonization regimens: Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that enrolled "subjects" represents 137 individual HCA Hospitals (representing \~235 ICUs) that have been randomized.

Who can participate

SexALL

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Inclusion Criteria: * Inclusion criteria includes all U.S. HCA hospitals with an adult ICU; * Note: Unit of randomization is the hospital, but the participants are hospital adult ICUs * All patients within adult ICUs are included, including rare patients \<18 years and \>=12 years. Exclusion Criteria: * Exclusion criteria includes ICUs with an average length of stay of less than 2 days; * HCA hospitals that are not able to transfer or merge data into the centralized data warehouse for the baseline and intervention periods of the study are also excluded.

What they're measuring

Number of Participants With ICU-attributable Staphylococcus Aureus Clinical Cultures

Timeframe: 18-month intervention

Trial details

NCT IDNCT03140423

SponsorHarvard Pilgrim Health Care

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-11-06

Results submitted2023-11-06

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